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5th Annual Gloria and Mark Snyder Symposium

5th Annual Gloria and Mark Snyder Symposium on Cancer Metabolism:
The intersection of Cancer Metabolism and the Tumor Microenvironment

April 10, 2018
8 am – 5 pm
Hilton Garden Inn, Stony Brook 

Metabolic alterations in tumor cells were first described by Otto Warburg almost 100 years ago. Over the past decade there has been a resurgence in cancer metabolism research. This research has considerably enhanced our understanding of metabolic changes that not only occur in cancer cells, but also the metabolic changes occurring during the transformation process. It has also become apparent that tumors have evolved numerous mechanisms to obtain the nutrients they need to grow and to cope with metabolic stress in the tumor microenvironment. Indeed, an aspect of cancer metabolism that is rapidly developing is the interaction of premalignant/tumor cells with the tumor microenvironment. One area of significant interest involves the supporting role of cancer associated fibroblasts and endothelial cells in the TME.  

The coordination of metabolic programs with immune cell function is a fundamental event in immunity. Immune cells are known for their ability to rapidly transition from resting to activated states in response to external stimuli.  The ability of tumor cells to dampen this response enables them to evade immune surveillance.  Therefore, another area of intense research is focused on the ability of cancer cells to regulate immune cell metabolism and hence activation.  The focus of this meeting is on fundamental links between metabolism and cancer.  In addition, a goal of this symposia is to increase the interest and research on the interaction between tumor cells and the tumor microenvironment.  

Defining the diversity of metabolic strategies employed by cancer cells and how their interactions with tumor microenvironment influence these metabolic changes is a major goal of this meeting. The ultimate goal identifying promising avenues in tumor metabolism that impact our understanding, diagnosis and treatment of cancer.

Keynote Speakers
Russell Jones, PhD
Goodman Cancer Research Centre
Department of Physiology • McGill University, Montreal, Canada

Dr. Jones' research is focused on identifying the metabolic and bioenergetic alterations that drive tumor formation in cancer and immune activation in the TME. His research is focused on the pathways that sense and signal metabolic status enabling tumor cells to survive and proliferate. In addition, his lab has conducted some of the groundbreaking research on the metabolic requirements for T-cell activation. Metabolic constraints in the tumor microenvironment can negatively impact anti-tumor T cell responses, in part by competition of tumor infiltrating lymphocytes (TIL) with tumor cells for available nutrients. This can lead to reduced cancer immunosurveillance and anti-tumor immunity, enabling tumors to develop and expand.

Deepak Nagrath, PhD
Department of Biological Engineering • University of Michigan, Ann Arbor, MI

Dr. Nagrath's research focuses on developing metabolic and nutritional systems biology approaches for cancer and other diseases. His lab uses a systems biology approach to identify the critical metabolic regulators of cancer metastasis and the role the tumor microenvironment plays in modulating cancer cell metabolism. His lab's long-term goal is to discover potential therapies that exploit metabolic vulnerabilities in cancer. 

Abbreviated Agenda

8  – 8:45 am Breakfast and Registration
8:45 – 9 am  Welcome and Opening Remarks
Yusuf Hannun, MD
Director, Stony Brook University Cancer Center
Patricia Thompson, PhD
Deputy Director of Research, Stony Brook University Cancer Center
9:00 – 10 am Keynote Speaker 1 
Russell Jones, PhD 
10 – 10:30 am Talk I
Richard Lin, MD 
10:30 – 10:45 am Coffee Break
10:45 – 11:15 am  Talk II
Cancer Lipid Metabolism at Stony Brook 
Lina Obeid, MD, Vice Dean of Cancer Research 
11:15 – 11:30 am Talk III
Luis Martinez, PhD 
11:30 am – Noon Poster Session 1
Noon – 1 pm Lunch
1  – 2 pm Keynote Speaker 2 
Deepak Nagrath, PhD
2 – 2:30 pm Talk I 
Mihaela Skobe, PhD 
2:30 – 2:50 pm Talk II 
Timothy Duong, PhD
2:50 – 3:10 pm Coffee Break/Group Photo
3:10 – 4:10 pm Poster Session II
4:10 – 5 pm Closing Remarks/Light Refreshments

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