Office
(631) 444-3080
Email
arthur.grollman@stonybrook.edu
Stony Brook Medicine
Department of Pharmacology
Health Sciences, T8, Room 160
101 Nicolls Road
Stony Brook, NY 11794
Arthur Grollman, MD
Professor, Department of Pharmacology,
Renaissance School of Medicine at Stony Brook University
Research Program
Oncogenic Drivers and Mechanisms of CarcinogenesisDepartment
Department of PharmacologyResearch Interest
Dr. Grollman has published more than 200 papers in the fields of molecular biology and cancer research. His current research interests focus on the biological consequences of DNA damage as they relate to molecular mechanisms of DNA replication, mutagenesis, and DNA repair. Research in the Grollman laboratory was instrumental in establishing the mechanism of action of the antitumor agent bleomycin and in defining the biochemical pathway that protects cells against mutations produced by oxidative DNA damage. Recently, he and his colleagues established the three-dimensional structures of DNA glycosylases and DNA polymerases bound to site-specifically modified DNA, thereby correlating molecular structure of damaged DNA with biologic function. Currently, he directs a research program focusing on the environmental and genetic causes of endemic nephropathy and its associated urothelial cancer.
Education
BA: University of California at BerkeleyMD: Johns Hopkins School of Medicine