Office 
(631) 632-8650

Email 
nancy.reich@stonybrook.edu

Stony Brook University
Department of Molecular Genetics and Microbiology
168 Life Sciences Building
100 Nicolls Road
Stony Brook, NY 11794

Research Program

Oncogenic Drivers and Mechanisms of Carcinogenesis

Department

Department of Molecular Genetics and Microbiology

Research Interest

Cytokine Signaling, Gene Expression, Immune Defense, Cancer

Immune defense, differentiation, programmed cell death, and malignancy are all influenced by extracellular cytokines. Our research centers on the action of a subset of cytokines that stimulate Janus tyrosine kinases (JAKs) and signal transducers and activators of transcription (STATs). Activated JAK-STAT pathways rapidly transduce signals from outside the cell into the nucleus to regulate gene expression. Although the JAK-STAT cytokines use similar signal transduction pathways, their biological effects are quite diverse. For example, interferons confer resistance to viral infections, whereas interleukin-6 promotes inflammation and malignancy. We are currently exploring mouse models of viral infection and pancreatic cancer to identify molecular mechanisms that can be used to combat these diseases.

Education

BA: Hofstra University
PhD: Stony Brook University
Postdoctoral Research: Rockefeller University 

Publications

A complete list of publications can be found HERE.