Bingham Research Lab
Paul M. Bingham, PhD
- Associate Professor, Department of Biochemistry and Cell Biology
Office: (631) 632-8548
Email: paul.bingham@stonybrook.edu
Stony Brook University450 Life Sciences Building
Stony Brook, NY 11794-5215
Research Program
Department
Research Interest
First, in collaboration with Research Assistant Professor Zuzana Zachar, PhD , Paul has been pursuing a novel approach to cancer chemotherapy. This approach exploits the now well-characterized differences in patterns of energy metabolism between tumor cells and normal. Lipoic acid is both a catalytic component of the two enzymes through which most carbon enters tumor cell mitochondria and the source of regulatory signals that control this carbon flux and tumor cell mitochondrial metabolism more generally. These regulatory signals and their targets are apparently so extensively different in tumor and normal cells that properly designed lipoate analogs – mis-informing these regulatory processes – can be used to selectively kill tumor cells.
Education
- PhD, Biochemistry and Molecular Biology at Harvard, 1980
