Frohman Research Lab

Michael Frohman

Michael A. Frohman, MD, PhD

  • Distinguished Professor and Chair, Pharmacological Sciences, Renaissance School of Medicine

Faculty Page

Office: (631) 632-1476

Email: michael.frohmane@stonybrookmedicine.edu

Stony Brook University
Basic Sciences Tower 8-140
Stony Brook, NY 11794-8651

Research Program

Department

Research Interest

The Frohman laboratory cloned and has been exploring translational roles for the mammalian family of lipid-signaling Phospholipase D genes for two decades. PLD superfamily members are involved in many physiological and pathophysiological settings including immune defenses, cancer, neurodegenerative disease, diabetes, cardiovascular disease, and fertility. Among other approaches, the lab has been generating and publishing findings using mice lacking each of the PLD isoforms, uncovering several discoveries with human health relevance.

Recent work has focused on exploring the potential of using a Phospholipase D small molecule inhibitor as a therapeutic in stroke, cardiovascular disease, and cancer progression. Cell biological processes of particular interest include mitochondrial fusion and fission, subcellular trafficking of membrane vesicles during signaling-activated exocytosis and endocytosis, viral trafficking through the Golgi complex, integrin activation, and receptor signaling.

Education

  • BS (High Honors), Chemistry & Cell & Molecular Biology, University of Michigan, Ann Arbor, 1978
  • MD, PhD, Medicine and Immunology, University of Pennsylvania, Philadelphia, 1985
  • Postdoc, Mammalian Developmental Biology, University of California at San Francisco, 1986–1992

Publications

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