Huang Research Lab
Chiung-Kuei Huang, PhD
- Associate Professor of Medicine, Division of Gastroenterology and Hepatology
- Director of Liver Research
Office: (631) 216-8919
Email: Chiung-kuei.huang@stonybrookmedicine.edu
Department of MedicineRenaisssance School of Medicine
Stony Brook University
HSC T17-090
101 Nicolls Road
Stony Brook, NY 11794-8173
Research Program
Department
- Department of Medicine, Division of Gastroenterology and Hepatology
Research Interest
Dr. Huang’s lab has been working on deciphering the molecular pathogenesis of liver malignancy. Characterizing molecular pathogenesis of liver tumors will yield results toward identifying potential therapeutic targets for these deadly diseases.
Key areas of study include: aspartate β-hydroxylase (ASPH), which catalyzes the hydroxylation of aspartate and asparagine residues within EGF-like domains, and ten-eleven translocation methylcytosine dioxygenase 1 (TET1), an enzyme responsible for generating 5-hydroxymethylcytosine and promoting DNA demethylation. Dr. Huang has demonstrated that ASPH is highly expressed in cholangiocarcinoma (CCA) but is minimally detectable in normal bile ducts.
Recent findings from his group indicate that several candidate compounds targeting ASPH enzymatic activity can effectively suppress CCA progression. Ongoing work aims to further define the therapeutic potential of these agents using multiple preclinical CCA models.
In parallel, Dr. Huang’s lab investigates TET1-mediated epigenetic regulation in the progression of alcohol-associated liver disease (ALD)–related hepatocellular carcinoma (HCC). These studies employ cell-type–specific TET1 knockout mouse models to dissect the role of TET1 in ALD/HCC pathogenesis. Since 2015, Dr. Huang’s research has been continuously funded by private foundations and federal agencies, including AASLD, NIH, and others.
Education
- Postdoctoral, Brown University
- PhD, University of Rochester
- MSc, National Sun Yat-Sen University
- BSc, National Sun Yat-Sen University
