Reich Marshall Research Lab

Nancy Reich Marshall, PhD

Nancy Reich Marshall, PhD

  • Professor, Department of Molecular Genetics and Microbiology

Office: (631) 632-8650

Email: nancy.reich@stonybrook.edu

Stony Brook University
Department of Molecular Genetics and Microbiology
168 Life Sciences Building
100 Nicolls Road
Stony Brook, NY 11794

Research Program

Department

  • Department of Molecular Genetics and Microbiology

Research Interest

  • Cytokine Signaling, Gene Expression, Immune Defense, Cancer 

Immune defense, differentiation, programmed cell death and malignancy are all influenced by extracellular cytokines. Our research centers on the action of a subset of cytokines that stimulate Janus tyrosine kinases (JAKs) and signal transducers and activators of transcription (STATs). Activated JAK-STAT pathways rapidly transduce signals from outside the cell into the nucleus to regulate gene expression. Although the JAK-STAT cytokines use similar signal transduction pathways, their biological effects are quite diverse. For example, interferons confer resistance to viral infections, whereas interleukin-6 promotes inflammation and malignancy. We are currently exploring mouse models of viral infection and pancreatic cancer to identify molecular mechanisms that can be used to combat these diseases.

Education

  • BA, Hofstra University
  • PhD, Stony Brook University
  • Postdoctoral Research, Rockefeller University

Publications

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