Ren Research Lab
Kehan Ren, PhD
- Assistant Professor of Medicine, Division of Hematology and Oncology, Renaissance School of Medicine
Office: (631) 638-3885
Email: Kehan.Ren@stonybrookmedicine.edu
Stony Brook UniversityHealth Science Center, T15-095
Stony Brook, NY 11794
Research Program
Department
Research Interest
Dr. Ren’s laboratory investigates how inflammatory remodeling of the bone marrow microenvironment shapes antigen presentation and T-cell fate decisions that drive clonal hematopoiesis and myeloid malignancy progression. The lab integrates iPSC-derived human bone marrow organoids, mouse models, and single-cell immune profiling to define immune–stromal circuits that promote pathologic myelopoiesis.
A central focus supported by an NCI K99/R00 grant is to elucidate how stromal Gasdermin D (GSDMD)–dependent signals program macrophage functions, including phagocytic activity and MHC class II–associated antigen presentation, and how these changes influence marrow CD4+ T-cell states during inflammatory myelopoiesis. By mechanistically interrogating stromal–myeloid–T-cell communication circuits, Dr. Ren’s lab aims to identify actionable bone marrow niche mechanisms that can be leveraged to restore hematopoietic homeostasis for mutant stem cell clones.
Education
- PhD, Pathology, Fudan University, Shanghai, China
- MS, Health and Biomedical Informatics, Northwestern University, Chicago, Illinois
- BS, Laboratory Medicine, Capital Medical University, Beijing, China
