Tonge Research Lab
Peter Tonge, PhD
- Distinguished Professor, Department of Chemistry
- Professor of Radiology (by courtesy)
- Affiliate Faculty, The Laufer Center for Physical and Quantitative Biology
Office: (631) 632-7907
Email: peter.tonge@stonybrook.edu
Department of ChemistryStony Brook University
100 Nicolls Road
Stony Brook, NY 11794-3400
Research Program
Department
- Department of Chemistry
- Department of Radiology (by courtesy)
Research Interest
Peter Tonge is interested in improving the selection and optimization of drug candidates by integrating drug-target binding kinetics, and factors such as target vulnerability and the rate of protein synthesis, into predictions of drug activity. Currently he is developing and analyzing inhibitors and targeted protein degraders of kinases such as Bruton’s tyrosine kinase (BTK), a target for hematological oncologies and autoimmune diseases, as well as protein arginine methyl transferase 5 (PRMT5), an enzyme that can be selectively targeted in 10-15% of cancers that have a deletion in the MTAP gene, and the immunooncology target indoleamine 2,3-dioxygenase 1 (IDO1). His lab also uses ultrafast spectroscopy and unnatural amino acid mutagenesis to site-specifically time-resolve structural dynamics during the activation of photoreceptors and optogenetic devices.
Education
- BSc, University of Birmingham, England
- PhD, University of Birmingham, England
- SERC-NATO Postdoctoral Research Fellowship, National Research Council Canada
