Office
(631) 638-1286
Email
Dongyan.Tan@stonybrook.edu
Stony Brook School of Medicine
Pharmacological Sciences
Basic Science Tower Room 7-127
101 Nicolls Road
Stony Brook, NY 11794
Dongyan Tan, PhD
Assistant Professor, Pharmacological Sciences
Stony Brook School of Medicine
Research Program
Imaging Biomarker Discovery and Engineering SciencesDepartment
Pharmacological SciencesResearch Interest
The primary goal of our research is to understand how epigenetic factors regulate gene expression and cellular activities during normal development, and how their dysregulation leads to diseases, particularly cancer. We combine structural biology, biochemistry, and various biophysical techniques, with a special focus on cryo-electron microscopy, to uncover the intricate molecular interactions that govern these processes. We aim to uncover the intricate molecular interactions governing these processes. The insights gained will be invaluable for developing new cancer therapies.
Our current research is focused on two key areas:
1. Investigating the role of histone variants in transcription and DNA damage repair.
2. Elucidating the mechanisms by which ATP-dependent chromatin remodeling enzymes regulate DNA repair and contribute to cancer development.
Education
BS: Sun Yat-Sen University, Guangzhou, Guangdong, China
PhD: Albert Einstein College of Medicine, Bronx, NY
Postdoc: Harvard Medical School, Boston, MA