Office 
(631) 632-8548

Email 
paul.bingham@stonybrook.edu

Stony Brook University
450 Life Sciences Building

Stony Brook, NY 11794-5215

Research Program

Lipid Signaling and Metabolism in Cancer

Department

Department of Biochemistry and Cell Biology

Research Interest

First, in collaboration with Research Assistant Professor Zuzana Zachar, PhD, Paul has been pursuing a novel approach to cancer chemotherapy. This approach exploits the now-well-characterized differences in patterns of energy metabolism between tumor cells and normal. Lipoic acid is both a catalytic component of the two enzymes through which most carbon enters tumor cell mitochondria and the source of regulatory signals that control this carbon flux and tumor cell mitochondrial metabolism more generally. These regulatory signals and their targets are apparently so extensively different in tumor and normal cells that properly designed lipoate analogs – mis-informing these regulatory processes - can be used to selectively kill tumor cells.

Education

PhD, Biochemistry and Molecular Biology at Harvard, 1980

Publications

A complete list of publications can be found HERE.