Contact Information

Office 
(631) 216-2926

Email 
Mehdi.Damaghi@stonybrookmedicine.edu

Stony Brook University
Address (TBD)
Stony Brook, NY 11794

image of Dr Damaghi
Damaghi Research Lab

Mehdi Damaghi, PhD

Assistant Professor, Department of Pathology,
Renaissance School of Medicine at Stony Brook University

Research Program

Lipid Signaling and Metabolism in Cancer

Department

Pathology

Research Interest

Evolution of metabolic phenotypes in variable tumor microenvironment
The central aim of my lab research is to use ecological-evolutionary principles to understand molecular mechanism of breast and ovarian cancer initiation, progression, and metastasis through adaptation to microenvironment. I hypothesize that evolution of new metabolic phenotypes under variable microenvironment selection can drive cancer through metabolic reprogramming linked to epigenetics and transcription factors activation and stabilization.

We study how the tumor adaptation can shape the new microenvironment and metabolism that shape emerging selective pressures. This interplay between tumor cells and microenvironment plays a fundamental role in development of ever-changing tumor ecosystem leading to more genotypic heterogeneity and phenotypic plasticity. We use integration of single cell genome, epigenome, transcriptome, proteome and metabolome, and pathomics analysis to capture the heterogeneity and plasticity of cancer cells in their natural context.

Here are the main four projects in the lab:
Project 1: Ecology and Evolution of Breast Carcinogenesis
Project 2: Metabolic phenotypes present in DCIS to stratify Disease progression and upstaging
Project 3: Co-evolution of tumor and stroma in breast cancer
Project 4: Evolution of resistant phenotype to PARPi in ovarian cancer: genotypic heterogeneity vs phenotypic plasticity

Education

BSc in Molecular and Cell Biology-genetics, Chamran University, Ahavz, Iran
MSc in Biochemistry, TMU, Tehran, Iran
PhD in Cell Biology and Genetic Engineering, Max Planck Institute, Dresden, Germany

Publications

A complete list of publications can be found HERE.