Office
(631) 722-2623
Email
ledong.wan@stonybrookmedicine.edu
Stony Brook University
Department of Biomedical Informatics
100 Nicolls Road
Stony Brook, NY 11794
Ledong Wan, PhD
Assistant Professor
Department of Pharmacological Sciences
Renaissance School of Medicine
Stony Brook University
Research Program
Oncogenic Drivers and Mechanisms of CarcinogenesisDepartment
Department of Pharmacological SciencesResearch Interest
RNA Metabolism, Pancreatic Cancer, Inflammation
Research Summary: Our laboratory seeks to understand the mechanisms by which RNA splicing is dysregulated to promote tumorigenesis and progression. We utilize transgenic mouse models and organoid culture to investigate the regulation of RNA splicing in physiological conditions and its dysregulation in inflammation and pancreatic cancer. Our expertise in small molecules and antisense technology enables us to modulate aberrant splicing for potential cancer therapy.
Education
2011 B.S. Pharmacology, China Pharmaceutical University, Nanjing
2014 M.S. Medicinal Chemistry, China Pharmaceutical University
2018 Ph.D. Pathology and Pathophysiology, Zhejiang University
2018 - 2023 Postdoctoral training, Cold Spring Harbor Laboratory, New York