Office 
(631) 216-9359

Email 
michael.mak@stonybrook.edu

Stony Brook Medicine
Department of Pharmacological Sciences
Basic Science Tower
101 Nicolls Road
Stony Brook, NY 11794

Research Program

Oncogenic Drivers and Mechanisms of Carcinogenesis

Department

Department of Pharmacological Sciences

Research Interest

Mechanical and biophysical signals are critical in proper tissue organization and function, and dysregulation of these signals can drive disease phenotypes, including cancer metastasis, drug resistance, and tissue fibrosis. The focus of the Mak Research Lab is centered on 3 inter-related directions: 1) Uncovering principles of cell mechanosensing of complex multifactorial signals, 2) synthesizing more realistic extracellular matrix material states, and 3) building next generation functional tissues and organs. Together, these directions mutually advance each other and aim to provide biophysical and mechanobiological insights toward understanding disease and development, especially in cancer, fibrosis, morphogenesis, and organogenesis; tools for improved biomaterials and biomimetics, with applications in novel therapeutics; and user-designable functional tissue and organ systems for advanced disease modeling and regenerative medicine. Toward understanding and building mechanobiological systems, our lab takes interdisciplinary and integrated approaches involving biomedical design, tissue engineering, biophysics, mechanics, materials science, biofabrication, bioprinting, microfluidics, computational modeling, bioinformatics, quantitative microscopy, and novel experimental systems.

Education

BS: Brown University
PhD: Cornell University
Postdoc: Massachusetts Institute of Technology; Boston University

Publications

A complete list of publications can be found here