Dr. Gilbert Rahme

Office 
(631) 689-8333

Email 
gilbert.rahme@stonybrookmedicine.edu

Stony Brook University
Address
Stony Brook, NY 11794

Research Program

Oncogenic Drivers and Mechanisms of Carcinogenesis

Department

Department of Pharmacological Sciences

Research Interest

Research Interest: Cancer epigenetics, Brain tumors, mouse modeling

Research Summary: The Rahme laboratory studies cancer epigenetics and how epigenetic reprogramming can drive tumorigenesis and tumor progression. We specifically focus on a type of brain tumor called glioma, of which the majority are driven by epigenetic reprogramming. We use next-generation sequencing techniques to discover epigenetic lesions that we then functionally annotate using in vitro and mouse modeling.

Education

2008 B.S. Biology and earth sciences, Lebanese University, Beirut, Lebanon

2010 M.S. Biology, American University of Beirut, Beirut, Lebanon

2017 Ph.D. Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH

2017-2023 Postdoctoral training, Harvard Medical School, Boston, MA

Publications

• Gilbert J. Rahme, Nauman M. Javed, Kaitlyn L. Puorro, Shouhui Xin, Volker Hovestadt, Sarah E. Johnstone, Bradley E. Bernstein (2023). Modeling epigenetic lesions that cause gliomas. Cell 186(17):3674. PMID: 37494934.
   
• Cyril Neftel, Julie Laffy, Mariella G. Filbin, Toshiro Hara, Marni E Shore, Gilbert J. Rahme, ..., Aviv Regev, Bradley E. Bernstein, Itay Tirosh, Mario L. Suvà (2019). An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. Cell 178(4):835-849. PMCID: PMC6703186. 
   
• Gilbert J. Rahme, Bryan W. Luikart, Chao Cheng, and Mark A. Israel (2018). A recombinant lentiviral PDGF-driven mouse model of proneural GBM. Neuro-Oncology 20(3):332-42.

Additional Publication URL:
Additional list of publications can be found here: Dr. Rahme Publications