Office
(631) 216-8919
Email
Chiung-kuei.huang@stonybrookmedicine.edu
Stony Brook Medicine, Department of Medicine
101 Nicolls Road HSC T17-090
Stony Brook, NY 11794-8173
Chiung-Kuei Huang, PhD
Associate Professor of Medicine
Division of Gastroenterology and Hepatology
Director of Liver Research
Renaissance School of Medicine at Stony Brook University
Renaissance School of Medicine at Stony Brook University
Research Program
Oncogenic Drivers and Mechanisms of Carcinogenesis
Department
Department of Medicine
Division of Gastroenterology and Hepatology
Research Interest
Dr. Huang’s lab has been working on deciphering the molecular pathogenesis of liver malignancy. Characterizing molecular pathogenesis of liver tumors will yield results toward identifying potential therapeutic targets for these deadly diseases.
Key areas of study include aspartate β-hydroxylase (ASPH), which catalyzes the hydroxylation of aspartate and asparagine residues within EGF-like domains, and ten-eleven translocation methylcytosine dioxygenase 1 (TET1), an enzyme responsible for generating 5-hydroxymethylcytosine and promoting DNA demethylation. Dr. Huang has demonstrated that ASPH is highly expressed in cholangiocarcinoma (CCA) but is minimally detectable in normal bile ducts.
Recent findings from his group indicate that several candidate compounds targeting ASPH enzymatic activity can effectively suppress CCA progression. Ongoing work aims to further define the therapeutic potential of these agents using multiple preclinical CCA models.
In parallel, Dr. Huang’s lab investigates TET1-mediated epigenetic regulation in the progression of alcohol-associated liver disease (ALD)–related hepatocellular carcinoma (HCC). These studies employ cell-type–specific TET1 knockout mouse models to dissect the role of TET1 in ALD/HCC pathogenesis. Since 2015, Dr. Huang’s research has been continuously funded by private foundations and federal agencies, including AASLD, NIH, and others.
Education
Postdoctoral: Brown University
Ph.D., University of Rochester
M.Sc., National Sun Yat-Sen University
B.Sc., National Sun Yat-Sen University
Publications
A complete list of publications can be found here.