Office
(631) 638-3885
Email
Kehan.Ren@stonybrookmedicine.edu
Stony Brook University
Health Science Center, T15-095
Stony Brook, NY 11794
Kehan Ren, PhD
Assistant Professor of Medicine
Division of Hematology and Oncology
Renaissance School of Medicine at Stony Brook University
Research Program
Oncogenic Drivers and Mechanisms of Carcinogenesis
Department
Department of Medicine
Division of Hematology and Oncology
Research Interest
Dr. Ren’s laboratory investigates how inflammatory remodeling of the bone marrow microenvironment shapes antigen presentation and T-cell fate decisions that drive clonal hematopoiesis and myeloid malignancy progression. The lab integrates iPSC-derived human bone marrow organoids, mouse models, and single-cell immune profiling to define immune–stromal circuits that promote pathologic myelopoiesis.
A central focus supported by an NCI K99/R00 grant is to elucidate how stromal Gasdermin D (GSDMD)–dependent signals program macrophage functions, including phagocytic activity and MHC class II–associated antigen presentation, and how these changes influence marrow CD4+ T-cell states during inflammatory myelopoiesis. By mechanistically interrogating stromal–myeloid–T-cell communication circuits, Dr. Ren’s lab aims to identify actionable bone marrow niche mechanisms that can be leveraged to restore hematopoietic homeostasis for mutant stem cell clones.
Education
PhD, Pathology, Fudan University, Shanghai, China
MS, Health and Biomedical Informatics, Northwestern University, Chicago, United States
BS, Laboratory Medicine, Capital Medical University, Beijing, China
Publications
A complete list of publications can be found here