“Ongoing research in our lab examines how each of these biological processes regulates the behavior of cancer cells and how each of these therapeutics work on cells. Further, it seeks to use this information to advance novel therapy into ultimate testing in humans, with the goal of developing new treatments that can treat or prevent cancer in people.”
Project One:
We are examining the role of cancer cell motility after cells have already moved to bone. We have synthesized a novel therapeutic that binds bone, inhibits cell movement, and demonstrated that it potently inhibits cancer from destroying bone. This is a major problem for patients with prostate, breast, lung, and other cancers. (BioRxiv 2025)
Project Two:
We are examining the fundamental biological pathways by which cells regulate motility and drive them to become cancer. (Nature Communications 2018, 2019; Molecular Cancer Therapeutics 2020).
Project Three:
We are examining the mechanism of action by which a potent inducer of anoikis operates in cancer cells. (Cancers 2024).
