Conference Agenda

Registration (Danfords Hotel & Marina, Port Jefferson, NY USA)

Reception  (Danfords Hotel & Marina, Port Jefferson, NY USA)

Registration / Breakfast

Welcome and opening address

Raymond Bergan, Director, Stony Brook Cancer Center

Ke Jian “Jim” Liu, conference organizer, Stony Brook University

Max Costa, conference co-organizer, New York University

Session #1: Human and Population Studies              

Session chairs:           Rebecca Fry, University of North Carolina Chapel Hill

                                    Paolo Boffetta, Stony Brook University

Rebecca Fry, University of North Carolina Chapel Hill
Inter and Trans-Generational Health Effects of Prenatal and Preconception Arsenic 
Exposure Tied to the Epigenome

Paolo Boffetta, Stony Brook University
Effect of occupational co- exposure to chromium (VI) and nickel and other carcinogens on risk of lung cancer

Natalie DuPré, University of Louisville
Multi-scale Assessments of Metal Exposures and Colorectal Cancer Risk: From Statewide Hotspots to Individual Biospecimens
Abstract not available at time of publication

Tiffani Fordyce, Exponent^®
An Updated Mortality Study of Beryllium Workers, 1925-2020


Jaymie R. Meliker, Stony Brook University
Cadmium, Antimony, and Incident Cardiovascular Disease in Never-Smokers: 
Case-Cohort Study in the Danish Diet Cancer and Health Cohort

Xuehong Zhang, Yale University
Environmental Metal Exposure and Liver Cancer: Molecular Pathways and Population Risks

Break Poster Viewing 

Session #2: Carcinogenic Properties of Iron 

Session chair: Konstantin Salnikow, National Cancer Institute     


Konstantin Salnikow, National Cancer Institute  
Introduction to ferroptosis


Brent Stockwell, Columbia University
Iron, Metabolism & Ferroptosis: Mechanisms and Therapeutic Implications
 

Richard Possemato, New York University
Iron sensing and metabolism in health and disease


Yatrik Shah, University of Michigan                
Mitochondrial Control of Iron Toxicity in Colorectal Tumors

Lunch Break (lunch provided)

Section #3:  Arsenic carcinogenesis mechanism and intervention

Session chairs: Chendil Damodaran (Texas A&M University)
                                                              

Chendil Damodaran, Texas A&M University  
Molecular Factors Contributing to Bladder Carcinogenesis by Low-Dose                                                     Arsenic.                                                   

XueFeng Ren, University at Buffalo 
Targeting Arsenic Toxicity: Mechanistic Insights and Intervention Strategies


Mayukh Banerjee, University of Louisville.
Small Dose, Big Impact: How Low Environmental Arsenic Exposure Causes Skin Cancer?


Yinsheng Wang, University of California Riverside                     
Molecular Mechanisms of Arsenic Toxicity – Protein Binding, Epigenetic Signaling, and DNA Repair


Gang Chen, University of Kentucky
STAT3 mediates arsenic-induced immunosuppression in the lung

Break Poster Viewing 

Session #4:Toxicity through Environment – Metal Interactions

Session chairs:           Lu Cai, University of Louisville

                                   Malek El Muayed, SUNY Upstate Medical University

Lu Cai, University of Louisville
Zinc and Cadmium Differentially Impact Diabetic/Metabolic CVDs

Malek El Muayed, SUNY Upstate Medical University
Influence of Zinc and Nickel on the Functional Regulation in Insulin Secreting Islets of Langerhans

Xixi Zhou, Stony Brook University
Deciphering Mutational Processes and Pathways Reshaped by Metals in UV-Induced Skin Carcinogenesis                               
 

Laurie Hudson, PhD, University of New Mexico
Thinking Zinc: An Intervention study for mitigation of metal toxicity

Breakfast

Session #5: metal dyshomeostasis in health and disease

Session chairs: Jamie Lynn Wise, University of Louisville

                          Ana Navis-Acien, Columbia University


Ana Navis-Acien, Columbia University
The Human Metallome and Brain Health: A Hypothesis for Dementia Risk


Shuk-mei Ho, University of Arkansas for Medical Sciences
How Early-Life Arsenic Exposure Impacts Sperm Quality and Reprograms the Epididymis Across Generations


Jamie Lynn Wise, University of Louisville
Toxicological perspective in the liver


Hui-Chen Wu, Columbia University
Arsenic and Liver Disease


Tongzhang Zheng, Brown University
The Joint Effects of Zinc, Nickel and Selenium on the Risk of Type 2 Diabetes
Abstract not available at time of publication

Break Poster Viewing 

Session #6:  Toxicity and carcinogenesis of chromium and other metals

Session chairs:           John Pierce Wise Sr., University of Louisville

John Vincent, University of Alabama

John Pierce Wise, Sr., University of Louisville
Like a Bull in a China Shop: Hexavalent Chromium Smashes the Genome in Human Lung Cells

John Vincent, University of Alabama
Do Ternary DNA-Cr(III)-Small Molecule Adducts Form? 
 

James T.F. Wise, Louisiana State University
Does Hexavalent Chromium Exposure Impact Metabolism?

Alicia Bolt, University of New Mexico
Uncovering Immune Dysregulation Mechanisms Triggered by Uranium Mine Dust Exposure        

Julie G. In, University of New Mexico
Uranium-Laden Particulate Dust Alters Intestinal Epithelial Proliferation and Differentiation

Lunch Break. (lunch provided)

Session #7: Mechanisms of metal toxicity and carcinogenesis (1/2) 

Session chairs: Bernardo Lemos, University of Arizona

                          Fei Chen, Stony Brook University


Bernardo Lemos, University of Arizona
Biomarkers of aging and environmental epigenetics


Hong Sun, New York University
Hexavalent chromium inhibits myogenic differentiation and muscle regeneration


Sebastian Medina, University of New Mexico
Defining Mechanisms of Arsenic-Induced Hematotoxicity Using Mouse and Human Hematopoietic Stem and Progenitor Cell Models


Suresh Cuddapah, New York University
Impact of nickel exposure on embryonic stem cell pluripotency


Donna Zhang, University of Florida
Arsenic promotes diabetes through altered carbohydrate metabolism


Yong Li, Baylor College of Medicine
Targeting p53 Mutants: from Arsenic to Antibody

Poster session (Coffee/refreshment/wine available)

Poster session (Coffee/refreshment/wine available)

Breakfast

Session #8: Mechanisms of metal toxicity and carcinogenesis (2/2) 

Session chairs:     Andrea Hartwig, Karlsruhe Institute of Technology, Germany 
                             Chengfeng Yang, Stony Brook University


Anatoly Zhitokovich, Brown University,
Bad influence: metal-induced proteotoxicity leading to DNA damage


Wing-Kee Lee, Bielefeld University, Germany
Cadmium cell death pathways in the kidney: Execution and evasion in carcinogenesis 


Fei Chen, Stony Brook University
Arsenic Disrupts H3K9me3 and H3K27me3 Balance by Biasing PRC2.1 and PRC2.2 Activity via PALI1 Inhibition in Carcinogenesis


Chengfeng Yang, Stony Brook University
Long noncoding RNA ABHD11-AS1 up-regulation promotes hexavalent chromium carcinogenesis


Andrea Hartwig, Karlsruhe Institute of Technology, Germany
Impact of arsenite and cadmium on cellular redox regulation involved in DNA damage response and epigenetics

Break Poster Viewing 

Session #9: Advanced technology and data science 

Session chairs: Ramana Davuluri, Stony Brook University
                         Changjian Feng, University of New Mexico 


Changjian (Jim) Feng, University of New Mexico 
Advanced Mass Spectrometry Strategies for Trace Metal Detection, Imaging, and Speciation in Biological Samples


Qun Liu, Brookhaven National Laboratory
Advanced structural biology and bioimaging technologies for exploring metal toxicity and carcinogenesis


Peng Mao, Stony Brook University
Mechanism of Transcription-coupled DNA Repair and its Impact on Cancer Mutations


Ramana Davuluri, Stony Brook University
Interpretation of Non-Coding Variants in Cancer Genomes - Application of Genomic Foundation Models on Whole Genome Sequence Data

Lunch Break (lunch provided)

Session #10: Resources, Grant, and Career Development
  

Frederick Tyson, National Institutes of Environmental Health
Abstract not available at time of publication
 

Konstantin Salnikow, National Cancer Institute
Abstract not available at time of publication

Section #11: Epigenetics and metals 

Session chairs: Koren Mann, McGill University, Canada
                         Chunyuan Jin, New York University


Koren Mann, McGill University, Canada
Arsenic Exposures and Sex-Specific Differences in Development of Atherosclerosis in Mice


Zuo Zhang, New York Univesity
Prevention of Chromium (VI)-Induced Carcinogenesis by Isohapontigenin


Alison Kupsco, Columbia University


Chunyuan Jin, New York University
Potential role of defective chromatin assembly in Alzheimer's disease        


Allison Kupsco, Columbia University
Associations of Children’s Urinary Metals with Blood RNA N6-Methyladenosine and 2’-O-Methyladenosine

Chunyuan Jin, New York University
Potential role of defective chromatin assembly in Alzheimer's disease

Shobhan Gaddameedhi, North Carolina State University
Environmental Circadian Disruption Alters the DNA Methylation and Transcriptomic Landscape in SKH-1 Mouse Skin after a Low Dose Arsenic and UVB Exposure

Closing Remarks