Sunday, October 26, 2025
3:00 - 8:00 pm | Registration (Danfords Hotel & Marina, Port Jefferson, NY USA) |
6:00 - 9:00 pm | Reception (Danfords Hotel & Marina, Port Jefferson, NY USA) |
Monday, October 27, 2025
(The Waterview at Port Jefferson Country Club, Port Jefferson)
7:30 - 8:30 am | Registration / Breakfast |
8:30 am | Welcome and opening address
Raymond Bergan, Director, Stony Brook Cancer Center
Ke Jian “Jim” Liu, conference organizer, Stony Brook University
Max Costa, conference co-organizer, New York University |
8:50 - 10:50 | Session #1: Human and Population Studies Session chairs: Rebecca Fry, University of North Carolina Chapel Hill Paolo Boffetta, Stony Brook University Rebecca Fry, University of North Carolina Chapel Hill Inter and Trans-Generational Health Effects of Prenatal and Preconception Arsenic Exposure Tied to the Epigenome Paolo Boffetta, Stony Brook University Effect of occupational co- exposure to chromium (VI) and nickel and other carcinogens on risk of lung cancer Natalie DuPré, University of Louisville Multi-scale Assessments of Metal Exposures and Colorectal Cancer Risk: From Statewide Hotspots to Individual Biospecimens Abstract not available at time of publication
Tiffani Fordyce, Exponent® An Updated Mortality Study of Beryllium Workers, 1925-2020
Jaymie R. Meliker, Stony Brook University Cadmium, Antimony, and Incident Cardiovascular Disease in Never-Smokers: Case-Cohort Study in the Danish Diet Cancer and Health Cohort
Xuehong Zhang, Yale University Environmental Metal Exposure and Liver Cancer: Molecular Pathways and Population Risks
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10:50 - 11:10 am | Break Poster Viewing |
11:10 - 12:30 pm | Session #2: Carcinogenic Properties of Iron Session chair: Konstantin Salnikow, National Cancer Institute
Konstantin Salnikow, National Cancer Institute Introduction to ferroptosis
Brent Stockwell, Columbia University Iron, Metabolism & Ferroptosis: Mechanisms and Therapeutic Implications Richard Possemato, New York University Iron sensing and metabolism in health and disease
Yatrik Shah, University of Michigan Mitochondrial Control of Iron Toxicity in Colorectal Tumors
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12:30 - 1:30 pm | Lunch Break (lunch provided) |
1:30 - 3:10 pm | Section #3: Arsenic carcinogenesis mechanism and intervention Session chairs: Chendil Damodaran (Texas A&M University) Chendil Damodaran, Texas A&M University Molecular Factors Contributing to Bladder Carcinogenesis by Low-Dose Arsenic. XueFeng Ren, University at Buffalo Targeting Arsenic Toxicity: Mechanistic Insights and Intervention Strategies
Mayukh Banerjee, University of Louisville. Small Dose, Big Impact: How Low Environmental Arsenic Exposure Causes Skin Cancer?
Yinsheng Wang, University of California Riverside Molecular Mechanisms of Arsenic Toxicity – Protein Binding, Epigenetic Signaling, and DNA Repair
Gang Chen, University of Kentucky STAT3 mediates arsenic-induced immunosuppression in the lung
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3:10 - 3:30 pm | Break Poster Viewing |
3:30 - 4:50 pm | Session #4:Toxicity through Environment – Metal Interactions Session chairs: Lu Cai, University of Louisville Malek El Muayed, SUNY Upstate Medical University Lu Cai, University of Louisville Zinc and Cadmium Differentially Impact Diabetic/Metabolic CVDs Malek El Muayed, SUNY Upstate Medical University Influence of Zinc and Nickel on the Functional Regulation in Insulin Secreting Islets of Langerhans
Xixi Zhou, Stony Brook University Deciphering Mutational Processes and Pathways Reshaped by Metals in UV-Induced Skin Carcinogenesis Laurie Hudson, PhD, University of New Mexico Thinking Zinc: An Intervention study for mitigation of metal toxicity |
Dinner on Your Own
Tuesday, October 28, 2025
(The Waterview at Port Jefferson Country Club, Port Jefferson)
8:00 - 9:00 am | Breakfast |
9:00 - 10:40 am | Session #5: metal dyshomeostasis in health and disease Session chairs: Jamie Lynn Wise, University of Louisville Ana Navis-Acien, Columbia University
Ana Navis-Acien, Columbia University The Human Metallome and Brain Health: A Hypothesis for Dementia Risk
Shuk-mei Ho, University of Arkansas for Medical Sciences How Early-Life Arsenic Exposure Impacts Sperm Quality and Reprograms the Epididymis Across Generations
Jamie Lynn Wise, University of Louisville Toxicological perspective in the liver
Hui-Chen Wu, Columbia University Arsenic and Liver Disease
Tongzhang Zheng, Brown University The Joint Effects of Zinc, Nickel and Selenium on the Risk of Type 2 Diabetes Abstract not available at time of publication |
10:40 - 11:00 am | Break Poster Viewing |
11:00 - 12:40 pm | Session #6: Toxicity and carcinogenesis of chromium and other metals
Session chairs: John Pierce Wise Sr., University of Louisville John Vincent, University of Alabama John Pierce Wise, Sr., University of Louisville Like a Bull in a China Shop: Hexavalent Chromium Smashes the Genome in Human Lung Cells John Vincent, University of Alabama Do Ternary DNA-Cr(III)-Small Molecule Adducts Form? James T.F. Wise, Louisiana State University Does Hexavalent Chromium Exposure Impact Metabolism? Alicia Bolt, University of New Mexico Uncovering Immune Dysregulation Mechanisms Triggered by Uranium Mine Dust Exposure Julie G. In, University of New Mexico Uranium-Laden Particulate Dust Alters Intestinal Epithelial Proliferation and Differentiation |
12:40 - 1:30 pm | Lunch Break. (lunch provided) |
1:30 - 3:30 pm | Session #7: Mechanisms of metal toxicity and carcinogenesis (1/2) Session chairs: Bernardo Lemos, University of Arizona Fei Chen, Stony Brook University
Bernardo Lemos, University of Arizona Biomarkers of aging and environmental epigenetics
Hong Sun, New York University Hexavalent chromium inhibits myogenic differentiation and muscle regeneration
Sebastian Medina, University of New Mexico Defining Mechanisms of Arsenic-Induced Hematotoxicity Using Mouse and Human Hematopoietic Stem and Progenitor Cell Models
Suresh Cuddapah, New York University Impact of nickel exposure on embryonic stem cell pluripotency
Donna Zhang, University of Florida Arsenic promotes diabetes through altered carbohydrate metabolism
Yong Li, Baylor College of Medicine Targeting p53 Mutants: from Arsenic to Antibody |
3:30 - 5:30 pm | Poster session (Coffee/refreshment/wine available) |
3:30 - 5:30 pm | Poster session (Coffee/refreshment/wine available) |
Dinner on Your Own
Wednesday, October 29, 2025
(The Waterview at Port Jefferson Country Club, Port Jefferson)
8:00 - 9:00 am | Breakfast |
9:00 - 10:40 am | Session #8: Mechanisms of metal toxicity and carcinogenesis (2/2) Session chairs: Andrea Hartwig, Karlsruhe Institute of Technology, Germany Chengfeng Yang, Stony Brook University
Anatoly Zhitokovich, Brown University, Bad influence: metal-induced proteotoxicity leading to DNA damage
Wing-Kee Lee, Bielefeld University, Germany Cadmium cell death pathways in the kidney: Execution and evasion in carcinogenesis
Fei Chen, Stony Brook University Arsenic Disrupts H3K9me3 and H3K27me3 Balance by Biasing PRC2.1 and PRC2.2 Activity via PALI1 Inhibition in Carcinogenesis
Chengfeng Yang, Stony Brook University Long noncoding RNA ABHD11-AS1 up-regulation promotes hexavalent chromium carcinogenesis
Andrea Hartwig, Karlsruhe Institute of Technology, Germany Impact of arsenite and cadmium on cellular redox regulation involved in DNA damage response and epigenetics |
10:40 - 11:00 am | Break Poster Viewing |
11:00 - 12:20 pm | Session #9: Advanced technology and data science Session chairs: Ramana Davuluri, Stony Brook University Changjian Feng, University of New Mexico
Changjian (Jim) Feng, University of New Mexico Advanced Mass Spectrometry Strategies for Trace Metal Detection, Imaging, and Speciation in Biological Samples
Qun Liu, Brookhaven National Laboratory Advanced structural biology and bioimaging technologies for exploring metal toxicity and carcinogenesis
Peng Mao, Stony Brook University Mechanism of Transcription-coupled DNA Repair and its Impact on Cancer Mutations
Ramana Davuluri, Stony Brook University Interpretation of Non-Coding Variants in Cancer Genomes - Application of Genomic Foundation Models on Whole Genome Sequence Data |
12:10 - 1:00 pm | Lunch Break (lunch provided) |
1:20 - 2:00 pm | Session #10: Resources, Grant, and Career Development Frederick Tyson, National Institutes of Environmental Health Abstract not available at time of publication
Konstantin Salnikow, National Cancer Institute Abstract not available at time of publication |
2:00 - 3:40 pm | Section #11: Epigenetics and metals Session chairs: Koren Mann, McGill University, Canada Chunyuan Jin, New York University
Koren Mann, McGill University, Canada Arsenic Exposures and Sex-Specific Differences in Development of Atherosclerosis in Mice
Zuo Zhang, New York Univesity Prevention of Chromium (VI)-Induced Carcinogenesis by Isohapontigenin
Alison Kupsco, Columbia University
Chunyuan Jin, New York University Potential role of defective chromatin assembly in Alzheimer's disease
Allison Kupsco, Columbia University Associations of Children’s Urinary Metals with Blood RNA N6-Methyladenosine and 2’-O-Methyladenosine Chunyuan Jin, New York University Potential role of defective chromatin assembly in Alzheimer's disease Shobhan Gaddameedhi, North Carolina State University Environmental Circadian Disruption Alters the DNA Methylation and Transcriptomic Landscape in SKH-1 Mouse Skin after a Low Dose Arsenic and UVB Exposure |
3:40 pm | Closing Remarks |
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Evening (6:00 - 9:00 pm)
Award Ceremony and Gala Dinner (Danfords Hotel& Marina, Port Jefferson, NY)