Conference Agenda

Registration (Danfords Hotel & Marina, Port Jefferson, NY USA)

Reception  (Danfords Hotel & Marina, Port Jefferson, NY USA)

Registration / Breakfast

Welcome and opening address

Raymond Bergan, Director, Stony Brook Cancer Center

Ke Jian “Jim” Liu, conference organizer, Stony Brook University

Max Costa, conference co-organizer, New York University

Session #1: Human and Population Studies
Session chairs: Rebecca Fry, University of North Carolina Chapel Hill 
                        Paolo Boffetta, Stony Brook University

Rebecca Fry, University of North Carolina Chapel Hill
Inter and Trans-Generational Health Effects of Prenatal and Preconception Arsenic Exposure Tied to the Epigenome

Paolo Boffetta, Stony Brook University
Effect of occupational co- exposure to chromium (VI) and nickel and other carcinogens on risk of lung cancer

Natalie DuPré, University of Louisville
Multi-scale Assessments of Metal Exposures and Colorectal Cancer Risk: From Statewide Hotspots to Individual Biospecimens

Tiffani Fordyce, Exponent^®
An Updated Mortality Study of Beryllium Workers, 1925-2020

Jaymie R. Meliker, Stony Brook University
Cadmium, Antimony, and Incident Cardiovascular Disease in Never-Smokers: Case-Cohort Study in the Danish Diet Cancer and Health Cohort

Xuehong Zhang, Yale University
Environmental Metal Exposure and Liver Cancer: Molecular Pathways and Population Risks

Break Poster Viewing 

Session #2: Carcinogenic Properties of Iron
Session chair: Konstantin Salnikow, National Cancer Institute (contractor)

Konstantin Salnikow, National Cancer Institute (contractor) 
Introduction to Ferroptosis
Abstract not available at time of publication

Brent Stockwell, Columbia University
Iron, Metabolism & Ferroptosis: Mechanisms and Therapeutic Implications

Richard Possemato, New York University
Iron sensing and metabolism in health and disease

Yatrik Shah, University of Michigan
Mitochondrial Control of Iron Toxicity in Colorectal Tumors

Lunch Break (lunch provided)

Section #3: Arsenic carcinogenesis mechanism and intervention
Session chairs: Chendil Damodaran, Texas A&M University 
                        Yinsheng Wang, University of California Riverside

Chendil Damodaran, Texas A&M University
Molecular Factors Contributing to Bladder Carcinogenesis by Low-Dose Arsenic

XueFeng Ren, University at Buffalo
Targeting Arsenic Toxicity: Mechanistic Insights and Intervention Strategies

Mayukh Banerjee, University of Louisville.
Small Dose, Big Impact: How Low Environmental Arsenic Exposure Causes Skin Cancer?

Yinsheng Wang, University of California Riverside
Molecular Mechanisms of Arsenic Toxicity – Protein Binding, Epigenetic Signaling, and DNA Repair

Gang Chen, University of Kentucky
STAT3 mediates arsenic-induced immunosuppression in the lung

Break Poster Viewing 

Session #4: Toxicity through Environment – Metal Interactions
Session chairs: Lu Cai, University of Louisville
                        Malek El Muayed, SUNY Upstate Medical University

Lu Cai, University of Louisville
Zinc and Cadmium Differentially Impact Diabetic/Metabolic CVDs

Malek El Muayed, SUNY Upstate Medical University
Influence of Zinc and Nickel on the Functional Regulation in Insulin Secreting Islets of Langerhans

Xixi Zhou, Stony Brook University
Deciphering Mutational Processes and Pathways Reshaped by Metals in UV-Induced Skin Carcinogenesis

Laurie Hudson, PhD, University of New Mexico
Thinking Zinc: An Intervention study for mitigation of metal toxicity

Breakfast

Session #5: metal dyshomeostasis in health and disease
Session chairs: Jamie Young Wise, University of Louisville 
                       Ana Navis-Acien, Columbia University

Ana Navis-Acien, Columbia University
The Human Metallome and Brain Health: A Hypothesis for Dementia Risk
Abstract not available at time of publication

Shuk-mei Ho, University of Arkansas for Medical Sciences
How Early-Life Arsenic Exposure Impacts Sperm Quality and Reprograms the Epididymis Across Generations
Abstract not available at time of publication

Jamie Lynn Wise, University of Louisville
Everything is ‘GUINEA’ Be Alright: Establishing a Novel In Vivo Model to Study Hexavalent Chromium Toxicity

Hui-Chen Wu, Columbia University
Arsenic Exposure and Liver Disease

Tongzhang Zheng, Brown University
The Joint Effects of Zinc, Nickel and Selenium on the Risk of Type 2 Diabetes
Abstract not available at time of publication

Break Poster Viewing 

Session #6: Toxicity and carcinogenesis of chromium and other metals 
Session chairs: John Pierce Wise Sr., University of Louisville
                       John Vincent, University of Alabama

John Pierce Wise, Sr., University of Louisville
Like a Bull in a China Shop: Hexavalent Chromium Smashes the Genome in Human Lung Cells

John Vincent, University of Alabama
Do Ternary DNA-Cr(III)-Small Molecule Adducts Form?

James T.F. Wise, Louisiana State University
Does Hexavalent Chromium Exposure Impact Metabolism?

Alicia Bolt, University of New Mexico
Uncovering Immune Dysregulation Mechanisms Triggered by Uranium Mine Dust Exposure

Julie G. In, University of New Mexico
Uranium-Laden Particulate Dust Alters Intestinal Epithelial Proliferation and Differentiation

Lunch Break. (lunch provided)

Session #7: Mechanisms of metal toxicity and carcinogenesis (1/2)
Session chairs: Bernardo Lemos, University of Arizona
                        Fei Chen, Stony Brook University

Bernardo Lemos, University of Arizona
Environmental Epigenetics and Novel Biomarkers of Aging

Hong Sun, New York University
Hexavalent chromium inhibits myogenic differentiation and muscle regeneration

Sebastian Medina, University of New Mexico
Defining Mechanisms of Arsenic-Induced Hematotoxicity Using Mouse and Human Hematopoietic Stem and Progenitor Cell Models

Suresh Cuddapah, New York University
Impact of nickel exposure on embryonic stem cell pluripotency

Donna Zhang, University of Florida
Arsenic promotes diabetes through altered carbohydrate metabolism

Yong Li, Baylor College of Medicine
Targeting p53 Mutants: from Arsenic to Antibody

Poster session (Coffee/refreshment/wine available)

Breakfast

Session #8: Mechanisms of metal toxicity and carcinogenesis (2/2)
Session chairs: Andrea Hartwig, Karlsruhe Institute of Technology, Germany 
                        Chengfeng Yang, Stony Brook University

Anatoly Zhitokovich, Brown University,
Bad influence: metal-induced proteotoxicity leading to DNA damage

Wing-Kee Lee, Bielefeld University, Germany
Cadmium cell death pathways in the kidney: Execution and evasion in carcinogenesis

Fei Chen, Stony Brook University
Arsenic Disrupts H3K9me3 and H3K27me3 Balance by Biasing PRC2.1 and PRC2.2 Activity via PALI1 Inhibition in Carcinogenesis

Chengfeng Yang, Stony Brook University
Long Noncoding RNA ABHD11-AS1 Up-Regulation Promotes Hexavalent Chromium Exposure-Induced Carcinogenesis

Andrea Hartwig, Karlsruhe Institute of Technology, Germany
Impact of arsenite and cadmium on cellular redox regulation involved in DNA damage response and epigenetics

Break Poster Viewing 

Session #9: Advanced technology and data science
Session chairs: Ramana Davuluri, Stony Brook University 
                        Changjian Feng, University of New Mexico

Changjian (Jim) Feng, University of New Mexico
Advanced Mass Spectrometry Strategies for Trace Metal Detection, Imaging, and Speciation in Biological Samples

Qun Liu, Brookhaven National Laboratory
Advanced structural biology and bioimaging technologies for exploring metal toxicity and carcinogenesis
Abstract not available at time of publication

Peng Mao, Stony Brook University
Genome-Wide Mapping Reveals Arsenic’s Role in Modulating UV Damage Formation and Repair

Ramana Davuluri, Stony Brook University
Interpretation of Non-Coding Variants in Cancer Genomes - Application of Genomic Foundation Models on Whole Genome Sequence Data

Lunch Break (lunch provided)

Session #10: Resources, Grant, and Career Development

Frederick Tyson, National Institutes of Environmental Health
Emerging research priorities at NIH and NIEHS…restoring public trust in science!
Abstract not available at time of publication

Konstantin Salnikow, National Cancer Institute (contractor)
Abstract not available at time of publication

Section #11: Epigenetics and metals
Session chairs: Koren Mann, McGill University, Canada 
                       Chunyuan Jin, New York University

Koren Mann, McGill University, Canada
Arsenic Exposures and Sex-Specific Differences in Development of Atherosclerosis in Mice

Shobhan Gaddameedhi, North Carolina State University
Environmental Circadian Disruption Amplifies Arsenic and UVB Co-Carcinogenicity by Altering the Methylation and Transcriptomic Landscape

Zhuo Zhang, New York University
Prevention of Chromium(VI)-induced Carcinogenesis by Isohapontigenin

Allison Kupsco, Columbia University
Associations of Children’s Urinary Metals with Blood RNA N6-Methyladenosine and 2’-O-Methyladenosin

Chunyuan Jin, New York University
Potential Role of Defective Chromatin assembly in Alzheimer's Disease

Closing Remarks