Daniel Canals, PhD
Research Assistant Professor, Department of Medicine,
Renaissance School of Medicine at Stony Brook University
Program Overview
My research is focused on the molecular mechanism of sphingolipids in cancer progression and metastasis. In my first postdoctoral position (Spanish National Research Council/University of Barcelona), I initiated my work in the sphingolipid field, designing and testing compounds as sphingolipid enzyme inhibitors with implications in cancer cell death by apoptosis and autophagy. I expanded my sphingolipid research with 4 years of postdoctoral training in sphingolipid and cancer research. I have focused on protein phosphatases and kinases as the downstream targets of the two major bioactive sphingolipids, ceramide and sphingosine-1-phosphate (S1P), and the effects on cytoskeleton reorganization during cancer progression. These studies have led to several peer-reviewed publications, including the regulation of the cytoskeletal ezrin protein by ceramide and S1P, and defining its molecular mechanism. Currently, as Research Assistant Professor, I am studying deeply the previous molecular mechanism of sphingolipids enzymes. Specifically, I am studying the direct molecular mechanism of activation of protein phosphatase 1 by sphingolipids and its implications in cytoskeleton re-organization during cell invasion.
Lab Members
Anne Ostermeyer-Fay
Senior Research Support Specialist
Education:
BA, Biology: Dowling College, Oakdale, New York
MA, Biology: State University of New York at Stony Brook, Stony Brook, New York
Contact Info:
anne.ostermeyer@stonybrookmedicine.edu
Ranjana Pathak
Senior Research Support Specialist
Education:
PhD Plant Sciences, NMBU, Norway (2021)
MA, Biology: State University of New York at Stony Brook, Stony Brook, New York
Contact Info:
Ranjana.Pathak@stonybrookmedicine.edu