Office
(631) 632-7907
Email
peter.tonge@stonybrook.edu
Stony Brook University
Department of Chemistry
100 Nicolls Road
Stony Brook, NY 11794-3400
Peter Tonge, PhD
Distinguished Professor, Department of Chemistry
Professor of Radiology (by courtesy)
Affiliate Faculty, The Laufer Center for Physical and Quantitative Biology
Stony Brook University
Research Program
Imaging, Biomarker Discovery and Engineering Sciences
Department
Department of Chemistry and Department of Radiology (by courtesy)
Research Interest
Peter Tonge is interested in improving the selection and optimization of drug candidates by integrating drug-target binding kinetics, and factors such as target vulnerability and the rate of protein synthesis, into predictions of drug activity. Currently he is developing and analyzing inhibitors and targeted protein degraders of kinases such as Bruton’s tyrosine kinase (BTK), a target for hematological oncologies and autoimmune diseases, as well as protein arginine methyl transferase 5 (PRMT5), an enzyme that can be selectively targeted in 10-15% of cancers that have a deletion in the MTAP gene, and the immunooncology target indoleamine 2,3-dioxygenase 1 (IDO1). His lab also uses ultrafast spectroscopy and unnatural amino acid mutagenesis to site-specifically time-resolve structural dynamics during the activation of photoreceptors and optogenetic devices.
Education
BSc, University of Birmingham, England
PhD, University of Birmingham, England
SERC-NATO Postdoctoral Research Fellowship, National Research Council Canada,
Publications
A complete list of publications can be found HERE.