Office
(631) 632-8813
Email
patrick.hearing@stonybrook.edu
Stony Brook Medicine
Department of Microbiology and Immunology
25A Life Sciences Building
101 Nicolls Road
Stony Brook, NY 11794
Patrick Hearing, PhD
Professor, Department of Microbiology and Immunology,
Renaissance School of Medicine at Stony Brook University
Research Program
Oncogenic Drivers and Mechanisms of CarcinogenesisDepartment
Department of Microbiology and ImmunologyResearch Interest
My laboratory studies the human DNA tumor virus adenovirus (Ad). Ad is an outstanding model system to study the regulation of numerous cellular processes including proliferation, gene expression, apoptosis, and host antiviral responses to infection. Recombinant Ad vectors also are promising agents for therapeutic gene delivery and as vaccine vectors. Ad generally causes mild infections of the respiratory and gastrointestinal tracts, but Ad infection may be severe in infants, the elderly and in immunocompromised individuals. Our research focuses on innate antiviral responses that are elicited during the early stage of viral infection and viral mechanisms that counteract these responses. The results provide fundamental insights into cellular and viral processes that inhibit or promote the viral replication program.