graphic for the International Ceramide Conference

PROGRAM

The 12th International Ceramide Conference will cover different aspects of Sphingolipid research, including:

  • Cancer Therapeutics
  • Physiology and Pathophysiology of Sphingolipid Metabolism
  • Regulation of Sphingolipid Metabolism
  • Regulation of Trafficking by Sphingolipids
  • Sphingolipids and Membrane Biophysics
  • Sphingolipids, Immunity, and Immunotherapy
  • Yeast and Plant Sphingolipid Biology

The scientific program includes keynote lectures, short talks selected from submitted abstracts, poster sessions, and “meet the experts” sessions. New for 2023 is the “Women in Sphingolipids” series, which is held on the morning after the official closing of the conference.

KEYNOTE PRESENTATIONS

IMAGE of Dr echten-deckert Dr. Gerhild van Echten- Deckert

Kekulé-Institute
Life & Medical Sciences Institute (LIMES)

Membrane Biology & Lipid Biochemistry
Gerhard-Domagk-Str. 1
53121 Bonn

g.echten.deckert@uni-bonn.de
Phone: +49 / (0)2 28 / 73 - 27 03 

 image of Dr Myles Cabot

Dr. Myles Cabot

Professor, Department of Biochemistry  and Molecular Biology

Brody School of Medicine
East Carolina University
600 Moye Blvd
Greenville, NC 27834

cabotm@ecu.edu
Phone: + 1 252-737-5020

 

Program Schedule
Sunday, April 16
4:00 pm - 6:00 pm Registration and Check-In
Main Lobby
6:00 pm - 7:00 pm Welcome Reception
Outside Sterling Hall @ firepit (weather permitting)
7:00 pm - 9:15 pm Dinner Buffet
Grand Magnolia Ballroom
7:30 pm - 7:45 pm Welcoming Remarks
7:45 pm - 8:45 pm Keynote presentations
7:45 pm - 8:15 pm "Sphingosine 1-phosphate a double-edged sword in the brain"
Gerhild van Echten-Deckert, Ph.D. LIMES Institute, University of Bonn, Germany
8:15 pm - 8:45 pm "From low-temperature lipases in the fat body of Sarcophaga bullata to upregulated ceramide clearance routes in drug-resistant cancer, all in 52 years!
Miles Cabot, Ph.D., East Carolina University, USA
8:45 pm - 9:00 pm Celebration of Mark Kester
Myles Cabot, Ph.D., East Carolina University, USA
Monday, April 17
8:00 AM - 8:30 AM Complete poster set-up
Grand Magnolia Foyer
8:30 am - 11:30 am Late Registration and Check-in
Grand Magnolia Foyer
8:30 am - 9:55 am Session 1 - Sphingolipids in Health and Disease Neurobiology
Grand Magnolia Ballroom
Co-Chairs: Stefka Spassieva and David Montefusco
8:30 am - 8:50 am "Sex and age-related differences in the brain expression of neural sphingomyelinase 2 may contribute to the increased susceptibility of women for neurodegenerative disease"
Afsana Khanam, Johns Hopkins University
8:50 am - 9:10 am "Alterations of Lipid-Mediated Mitophagy Result in Aging-Dependent Sensorimotor Defects"
Natalia Oleinik, Medical University of South Carolina
9:10 am - 9:25 am "Characterizing the Role of Sphingolipids in a Novel Mouse Model for Charcot-Marie-Tooth Disease"
Keila Espinoza, University of Arizona
9:25 am - 9:40 am "Exploring the Mechanistic Link Between Mitochondrial Dysfunction and Neuronal Death in Alzheimer's Disease: Investigating the Therapeutic Potential of Ceramide Analog Druc LCL768"
Chase Walton, Medical University of South Carolina
9:40 am - 9:55 am "1-Deoxysphingolipid neurotoxicity"
Susana Munoz-Gil, University of Kentucky
9:55 am - 10:15 am Mid-morning break
Grand Magnolia Foyer
10:15 am - 11:40 am Session 1 - Sphingolipids in Health and Disease (cont'd)
Cardio-metabolic Disease
Grand Magnolia Ballroom
Co-Chairs: Stefka Spassieva and David Montefusco
10:15 am - 10:30 am "SPTLC3-Generated Atypical Sphingolipids as Regulators of Hepatic Glucose Production"
David Montefusco, Virginia Commonwealth University
10:35 am - 10:55 am "Increased denova Biosynthesis Exasperates Sphingolipid Accumulation and contributes to cell death in Niemann-Pick Typ C Disease"
Jason Newton, Virginia Commonwealth University
10:55 am - 11:10 am "Ceramides as Mediators of Metabolic-associated Fatty Liver Disease: iCC conference"
Mariah Weber-Stout, University of Utah
11:10 am - 11:25 am "Impaired Cardiac Function and Pathology in Acid Ceramidase Deficient Mice"
Annie Kleynerman, Medial College of Wisconsin
11:25 am - 11:40 am "Knockout of Serine Palmitoyltransfease 3 (SPTLC3) leads to mitochondrial dysfunction in liver"
Maryam Jamil, Virgina Commonwealth University
11:45 am - 12:45 pm Lunch Buffet
Grand Magnolia Foyer
12:45 pm - 2:30 pm Session 2 Sphingolipids in Immunology and Infection
Grand Magnolia Ballroom
Co-Chairs: Menal Mehrotra and Jeremy Hengst
12:45 pm - 1:05 pm "Sphingolipids as Regulators of Immunogenic Cell Death"
Jeremy Hengst, Pennsylvania State University
1:05 pm - 1:25 pm "Dietary long-chain omega-3 fatty acids modify sphingolipid metabolism and increase airway hyperreactivity"
Tilla Worgall, Columbia University
1:25 pm - 1:45 pm "Targeting Lipid Metabolism To Treat And Prevent Fungal Infections"
Nivea pereira de Sa, Stony Brook University
1:45 pm - 2:00 pm "Disentangling the roles of sphingolipids during Mycobacterium tuberculosis infection"
Gaelen Guzman, Oregon Health Science University
2:00 pm - 2:15 pm "Acid ceramidase expression is crutcial for maintaining B cell numbers in mice and reduces IFNg secretion by mouse CD4+ T cells"
Putri Mandasari, University of Wurzburg
2:15 pm - 2:30 pm "Altered sphingolipid metabolism in community acquired pneumonia"
Kurt Stollberg, Jena University Hospital
2:30 pm - 4:30 pm Poster session 1
Grand Magnolia Foyer
4:30 pm - 5:15 pm Transportation to Charleston City Marina
17 Lockwood Drive, Charleston SC 29401
Outside Hotel lobby
5:30 pm - 6:00 pm Boarding
6:00 pm - 9:00 pm Dinner Cruise "Charleston Princess"
9:00 pm - 10:00 pm Transportation to Hyatt
Tuesday, April 18
8:30 am - 11:30 am Session 3 - Sphingolipid Signaling
Grand Magnolia Ballroom
Co-Chairs: Stephanie Xie and Can Senkal
8:30 am - 8:50 am "Functional Interplay between ER-stress dependent kinase PERK and Ssphingolipids"
Dariusz Pytel, Medical University of South Carolina
8:50 am - 9:10 am "Ceramide-dependent endothelial barrier disruptive effects of circulation bioactive lipids in severe COVID-19"
Alexander Borowiec, National Jewish Health
9:10 am - 9:30 am "Sphingosine-1-phosphate signaling regulates iintracullar complement activation to induce cancer metastasis"
Alhaji Janneh, Medical University of South Carolina
9:30 am - 9:45 am "Myristate-induced sphingolipid dysregulation results in endoplasmic reticulum stress in intestinal epithelial cells"
Chelsea Doll, University of Arizona
9:45 am - 10:00 am "P53-CerS6 interaction on endoplasmic reticulum in response to cell stress"
Madeline Hall, University of North Carolina
10:00 am - 10:15 am "Regulation of Ferroptosis by Ceramide Synthase-Generated Ceramide"
Sachin Kempelingaiah, Virginia Commonwealth University
10:15 am - 10:35 am Mid-morning break
Grand Magnolia Foyer
10:35 am - 11:30 am

Session 3 - Sphingolipid Signaling (cont'd)
10:35 am - 10:55 am "The sphingosine-1-phosphate receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance"
Zhihui Zhu, University of Kentucky

10:55 am - 11:15 am

 "Inhibiting SPHK2/S1P Axis Overcomes Myeloid-Derived Suppressor Cell-Driven Immunosuppression and Improves Tumor Control"
Shikhar Mehrotra, Medical University South South Carolina
11:15 am - 11:30 am "Exploring the Role of a Glucosylceramide transporter, Atp 10D, in Metabolic Disease"
Alex Mansueto, Vanderbilt University
11:30 am - 12:00 pm Group Photo
Location to be announced
12:00 pm - 1:00 pm Lunch Buffet
Grand Magnolia Foyer
1:00 pm - 3:30 pm Session 4 - Novel Tools and Methods in Sphingolipids
Grand Magnolia Ballroom
Co-Chairs: Daniel Canals and Justin Snider
1:00 pm - 1:20 pm "A novel method for isolation of extracellular vesicles (EVs) from brain tissue using gentle proteolytic dissociation and membrane affinity capture"
Ahmed Elsherbini, University of Kentucky
1:20 pm - 1:40 pm "Synthesis of a GM1 structural library reveals distinct membrane and trafficking behavior based on ceramide structure"
Stefanie Schmieder, Harvard Medical School
1:40 pm - 2:00 pm "A method to detect and quantify ceramide and the plasma membrane"
Daniel Canals, Stony Brook University
2:00 pm - 2:20 pm "Direct Targeting of Protein-Membrane Interactions"
Johannes Morstein, University of California, San Francisco
2:20 pm - 2:40 pm "Low-input lipidomics to dissect human hematopoietic stem cell heterogeneity"
Stephanie Xie, University Health Network
2:40 pm - 3:00 pm "How lipid composition contributes to tissue patterning? Tracing single-cell lipidomes"
Agostina Crotta Asis, Swiss Federal Institute of Technology
3:00 pm - 3:20 pm "The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway"
Tania Santos, Weizmann Institute 
3:30 pm - 5:30 pm Poster session 2
Grand Magnolia Foyer
5:30 pm  Dinner on your own in Charleston
Wednesday, April 19
 8:30 am - 10:15 am Session 5 - Sphingolipids inn Cancer
Grand Magnolia Ballroom
Co-Chairs: Chris Geen and Todd Fox
8:30 am - 8:50 am "Sexual dimorphism in hepatocellular carcinoma: a role for sphingolipids"
Chris Green, Virginia Commonwealth University
8:50 am - 9:10 am "Targeting mitochondrial membrane potential with organic cations enhances the anti-leukemic effects of ceramide nanoliposome"
Kelsey Fisher-Wellman, East Carolina University
9:10 am - 9:30 am "BXQ-350: Modulating Ceramide and Sphingosine-1-Phosphate for Anti-Tumor Activity in Cancer Patients with Advanced Disease"
Gilles Tapolsky, Bexion Pharmaceuticals
9:30 am - 9:45 am "Neutral sphingomyelinase-2 (nSMase2) suppresses tumor-intrinsic growth in breast cancer"
Andrew Resnick, Stony Brook University
9:45 am - 10:00 am "Lipid metabolism alterations promote PD-L1 internalization of oncogenic signaling to enhance TNBC migration and metastasis"
Wyatt Wofford, Medical University of South Carolina
10:00 am - 10:15 am "The pioneer transcription factor FOXA1 as a master-regulator of sphingolipid metabolism in breast cancer"
Sam Chiappone, Stony Brook University
10:15 am 10:35 am Mid-morning break
Grand Magnolia Foyer
10:35 am - 12:15 pm Session 5 - Shingolipids in Cancer (cont'd)
10:35 am - 10:55 am "CD36-Sphingosine 1-Phosphate Axis in Non-Malignant Osteoblasts Contributes to Osteosarcoma Progression"
Meenal Mehrotra, Medical University of South Carolina
10:55 am - 11:15 am "Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation"
Bruno Sequi, Paul Sabatier University
11:15 am - 11:30 am "The role of SPNS2 in cancer cell migration metastasis"
Han Lee, Medical University of South Carolina
11:30 am - 11:45 am "Ceramide Delivery Targets Mitochondrial Metabolism Through Alterations in the Mitochondrial Glycosphingolipid Landscape Chronic Lymphocytic Leukemia"
Luke Vass, University of Virginia
11:45 am - 12:00 pm "Co-targeting Glucosylceramide Synthase and Serine Palmitoyl Transferase for Colon Cancer Therapy"
Allie Straus, Virginia Commonwealth University
12:00 pm - 12:15 pm "Synergistic Lethality of Acid Ceramidase and Bcl-2 Inhibition in Acute Myeloid Leukemia is by Characterized Integration Stress Response Activation and Mitochondrial Impairment"
Johnson Ung, University of Virginia
12:15 pm - 7:00 pm Free Time
7:00 pm - 10:00 pm Dinner Banquet and Award Presentations
Grand Magnolia Room
Thursday, April 20
9:00 am - 11:00 am  Women in Sphingolipids Discussion Panel
(optional session)
Carolina / Palmetto room